Domestic benchmark index NSE Nifty fell 79.4 points to 24637.2, while the BSE Sensex traded 285.3 points down at 81088.45.
On the other hand, Deepak Fertilisers, AXISCADES Engg Tech, Authum Investment, Radico Khaitan and Shree Vasu Logistics stocks hit their fresh 52-week highs today.
In the Nifty 50 index, Eternal, M&M, Hindalco, HDFC Bank and Shriram Finance were among the top gainers on the NSE.
Coal India Ltd, Bajaj Finance, Apollo Hospital, L&T and SBI Life were among the top losers.